Below is a press release from the Wilmington-based Charles River Labs:
WILMINGTON, MA — Charles River Laboratories International, Inc. and Purespring Therapeutics, a pioneering gene therapy company focused on transforming the treatment of kidney diseases, recently announced a plasmid DNA contract development and manufacturing organization (CDMO) collaboration.
Supporting the first gene therapy platform targeting renal diseases, which affect approximately 840 million people, or around 10 percent of the global population, the program leverages Charles River’s established plasmid platform, eXpDNA™, and decades of experience at the Company’s plasmid DNA manufacturing center of excellence.
Purespring is engaged in the development of novel therapies which have the potential to stop or significantly slow down chronic kidney diseases for which there is no current therapy available, except for dialysis or transplantation. With an innovative focus on the podocyte, a specialized kidney cell type implicated in many kidney diseases, Purespring’s Adeno Associated Virus (AAV) based gene therapy presents a lower-dose, local delivery approach which maximizes both safety and efficacy, as well as lowering the cost of goods.
Plasmid DNA CDMO Services
Expanding its comprehensive cell and gene therapy portfolio to span plasmid DNA, viral vector, and cell therapy production, through the acquisitions of Cobra Biologics, Vigene Biosciences, and Cognate BioServices in 2021, and in addition to recent expansion projects, Charles River offers end-to-end support and supply chain simplification for developers seeking to accelerate their program while ensuring the highest quality control.
The eXpDNA plasmid manufacturing platform builds on Charles River’s proven plasmid DNA CDMO capabilities and processes, fine-tuned over decades successfully supporting vaccine and advanced therapy clients through clinical trials and beyond.
“Purespring’s unique and targeted approach has the potential to radically change the treatment of kidney diseases. Their work is incredibly important to patients worldwide, and we are thrilled to collaborate,” said Kerstin Dolph, Corporate Senior Vice President, Biologics Solutions, Charles River.
“Our team is proud to be leading a revolution in the treatment of kidney diseases and understands that a key factor to our success is developing a robust and reliable CMC platform. Purespring’s established relationship with Charles River leverages a breadth of contract development and manufacturing experience and expertise,” added Julian Hanak, Chief Executive Officer, Purespring Therapeutics.
About Charles River
Charles River provides essential products and services to help pharmaceutical and biotechnology companies, government agencies and leading academic institutions around the globe accelerate their research and drug development efforts. Our dedicated employees are focused on providing clients with exactly what they need to improve and expedite the discovery, early-stage development and safe manufacture of new therapies for the patients who need them. To learn more about our unique portfolio and breadth of services, visit www.criver.com.
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